Interesting thread this. I'm more into Science Fiction myself, but then I have read Fantasy in the past, although LoTR bored me to tears and now cannot stand anything by Tolkien. I really enjoyed the Thomas Covenent series (the first set, second set were rubbish IMHO), and a couple of others, but that's the only one that really stands out in my mind.
When it comes to Science Fiction though, I have read as much as I can over the years, and for one specific genre, it sure has a hell of a lot of sub-genres to it (Detective, Humour, etc). My favourites (to name a few) include The War Against The Chtorr by David Gerrold, Babylon 5: Legions of Fire by Peter David, Nights Dawn Trilogy by Peter Hamilton, and quite a few more that I can't carry on listing like some kinda drone.
But then there is the Fantasy/Science Fiction crossover that a certain authoress by the name of Julian May did so well with The Sage of The Exiles (Fantasy with hints of Science Fiction) and The Galactic Milieu Trilogy (Science Fiction with a hint of Fantasy). So, it's best not to write the genre off completely, it has it's uses after all...
*rubs chin*