Hey,
@Danny McG. If the sassy housekeeper could be Sebastian Cabot, then you may be looking for
Family Affair. Brian Keith's character takes care of his deceased brother's kid
s. But there is a young boy and two young girls, rather than two boys. An entertaining show, in its day. Here is the IMDB listing:
30m | TV-G
www.imdb.com
Maybe there was another, similar show in the '60s, but I cannot think of it, CC
edit to add: Keith's character was a wealthy bachelor who lived in a high-rise in NYC.
Also, the youngest girl and the young boy were twins... maybe there is rivalry here? Cannot remember, I likely haven't seen an episode in 40 years.
edit 2: I am down the rabbit hole on this... according to Wikipedia, in the show's last season, the actress Nancy Walker is brought in to the series to play a housekeeper hired to assist Sebastian Cabot's character. She could be your sassy housekeeper!
en.wikipedia.org