In this instance I don't think the problem is as pronounced because of the fluid (how woke am I) way the DR can regenerate. Having a female Iron Man or a female Thor though is just co-opting a character IMO.While I see the merit in wanting original strong female characters and share the desire, I don't think this is as politically problematic as you think. It really depends on how it is framed within the universe and so far, the gender change has been rather ignored.
I think original and powerful stories for female leads already exist and more are being written everyday. and I welcome more of it.