If everyone is eventually doomed, why not meet your end on home turf rather than the middle of nowhere?
That is a good question, and there is no easy answer. To some home turf is exactly the kind of place where one could survive - if there is everything one needs. But the problem with most people is that they tend to live in highly populated places instead of countryside or remote locations, like the Catarina Island. In the zombie apocalypse none of the places are exactly safe as we saw from the floaters coming to shore, and knowing the fact that eventually everyone turns in their moment of death - if their brain isn't damaged.
What I did find incredible in this episode was that even though the people have the knowledge, they still tend to do the stupid thing, as we saw happening to Melissa, when she ran upstairs to take care of Willa. She forgot everything. Melissa didn't seem to grasp the fact that there is no way save anyone after they've died. CPR doesn't work, because the patient will turn and bite the carer.
The pill Willa took was either a lithium capsule or then it was an antibiotic called minocycline, according to the drugs.com medicine identifier. But for the sake of storytelling we have to take it granted that it was possibly something else that George had hid inside the globe. What for? I don't know and I doubt we will ever find out because I doubt FTWD crew will ever return to that island.
Thing is that for the sake of survival they should have tried to gather supplies to Abigail, instead of just being shocked about the fact that the dead has an ability to cross long distances that the Pacific Ocean presents to them. The one thing they should have done was to top of Abigail's fuel tanks as nobody knows when they have another chance to do such a thing.
But they didn't. Nobody didn't even thought about that. Not even Strand, who seem to have an idea of heading down towards South and possibly meet with whoever was at the other end of that line. My suspicion is that it was a cartel man.
A question: how long it will take for these people to really learn that the living are the worst? And that given an opportunity scavenging supplies should be the top priority?
Additional musing goes to Nicholas doing to the usual thing. Addiction will never go away.